Nikos Makris


Assistant Professor of Neurology, Harvard Medical School






Boston University

University of Siena, Italy





Behavioral Neuroscience



Positions and Honors


            1978-1985       Research Assistant, Microbiology Laboratory, University of Siena, Italy

            1985-1989       Residence, Department of Anesthesiology, University of Siena, Italy

            1985-1989       Research Fellow, Medical Physics Laboratory, University of Siena, Italy

            1986-1989       Visiting Scientist and Lecturer, School of Posturography and Biomagnetism, UFR-Paris-

                                    Nord, Bobigny, France

            1989-1990       Research Fellow, Institute of Nervous and Mental Disorders (Psychiatry Residence)

                                    University of Siena, Italy

            1990-1991       Full time Residence, Department of Psychiatry, University of Siena, Italy

            1991-1994       Part time Residence, Department of Psychiatry, University of Siena, Italy

            1991-1994       Research Fellow, Neuropsychology Laboratory, Massachusetts General Hospital, Harvard

                                    Medical School, Boston, MA

            1992-1995       Research Scientist, Neuroanatomy Laboratory, Edith Nourse Rogers Memorial V.A. Medical

                                    Center, Bedford, MA

            1994-1999       Research Fellow, Center for Morphometric Analysis, Massachusetts General Hospital

                                    Boston, MA

            1999- 2003      Instructor of Neurology, Harvard Medical School, Boston, MA

            1999- present  Director of Neuroanatomy, Center for Morphometric Analysis, Massachusetts General Hospital

                                    Boston, MA

            2001- present  Director, Center for Morphometric Analysis, Massachusetts General Hospital

                 Boston, MA

            2002- present  Director, Martinos Center Morphometry Service, Martinos Center, Massachusetts General

                                    Hospital, Boston, MA

            2003- present  Assistant Professor of Neurology, Harvard Medical School, Boston, MA

            2004- present  Adjunct Assistant Professor, Department of Anatomy and Neurobiology, Boston University

                                    School of Medicine, Boston, MA



            1998                Winner of Henry I. Russek First Prize Award - Boston University School of Medicine

            1998                Winner of The Carol Biber Award in Behavioral Neuroscience - Department of Behavioral

                                    Neurosciences - Boston University School of Medicine

            1990-1991       Fellowship from the Italian Foreign Ministry


Selected peer-reviewed publications


Makris N., Kennedy DN, McInerney S, Sorensen AG, Wang R , Caviness VS, Pandya DN. Segmentation of Subcomponents within the Superior Longitudinal Fascicle in Humans: A Quantitative, In Vivo, DT-MRI Study. Cereb Cortex, 2004;(in press).


Makris N., Gasic GP, Seidman LJ, Goldstein JM, Gastfriend DR, Elman I, Albaugh DM, Hodge SM, Ziegler DA, Sheahan F, Caviness VS Jr., Tsuang MT, Kennedy DN, Hyman SE, Rosen BR, Breiter HC. Decreased Absolute Amygdala Volume in Cocaine Addicts. Neuron, 2004;(in press).


Makris N., Hodge SM, Haselgrove C, Kennedy DN, Dale A, Fischl B, Rosen BR, Harris G, Caviness VS,

Jr, and Schmahmann JD. Human Cerebellum: Surface Assisted Cortical Parcellation and Volumetry with Magnetic Resonance Imaging. Journal of Cognitive Neuroscience, 2003, 15:4, 1-16.


Herbert MR, Ziegler D, Deutsch c, O’Brien L, lange N, Bakardjiev A, Hodgson J, Adrien, K Steele, S, Makris N,

Kennedy DN, Harris G, Caviness VS Jr. Dissociations of cvereb ral cortex, subcortical and cerebral white matter

volumes in autistic boys. Brain, 2003, 126(5): 1182-1192.


Tuch DS, Reese TG, Wiegell MR, Makris N, Belliveau JW, Wedeen VJ. High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity. Magnetic Resonance in Medicine, 2002; 48: 577-582.


Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM. Whole Brain Segmentation: Automated Labeling of Neuroanatomical Structures in the Human Brain. Neuron, 2002, 33, 1-20.


Caviness VS Jr., Makris N, Montinaro E, Sahin NT, Bates JF, Schwamm L, Caplan D, and Kennedy DN.  Anatomy of stroke, part I: An MRI-based topographic and volumetric system of analysis.  Stroke, 2002, 33(11): 2549-56.


Caviness VS Jr, Makris N, Montinaro E, Sahin N, Bates JF, Schwamm L, Caplan D, and Kennedy DN.  Anatomy of a stroke, part II: Volumetric characteristics with implications for the local architecture of cerebral perfusion system.  Stroke, 2002, 33(11):2557-64.


Seidman LJ, Faraone SV, Goldstein JM, Kremen WS, Horton NJ, Makris N, Toomey R, Kennedy D, Caviness VS, Tsuang MT.  Left hippocampal volume as a vulnerability indicator for schizophrenia: An MRI morphometric study of non-psychotic first degree relatives. Archives of General Psychiatry, 2002; 58: 839-849.


Makris N, Papadimitriou GM, Worth AJ, Jenkins BG, Garrido L, Sorensen AG, Wedeen VJ, Tuch DS, Wu O,

Cudkowicz ME, Caviness VS, Rosen BR, Kennedy DN. Diffusion Tensor Imaging. Neuropharmacology: The Fifth Generation of Progress , Vol. 3 (27), Lippincott Williams & Wilkins, 2002.


Makris N, Pandya DN, Normandin JJ, Papadimitriou GM, Rauch SL, Caviness VS, Kennedy DN. Diffusion

Tensor-MRI Investigations of the Human Cingulum Bundle. CNS Spectrums, 2002, 7(7): 524-528.


Poellinger A, Thomas R, Lio P, Lee A, Makris N, Rosen BR, Kwong KK. Activation and Habituation in Olfaction-An fMRI Study. NeuroImage 13, 547-560, 2001.


Goldstein J, Seidman L, Horton N, Makris N, Kennedy N, Caviness V, Faraone S, Tsuang M.  Sexual

dimorphism of the adult human brain is associated with sex steroid determinants early in development. Cereb             Cortex, 2001; 11:490-497.


Meyer, J., Makris N., Bates, J. , Caviness VS, and Kennedy DN. MRI-Based Parcellation of  Human Cerebral White Matter. Part I: Technical Foundations. NeuroImage, 9, 1-17, 1999.


Makris N., Meyer, J., Bates, J. , Yeterian EH.,  Kennedy DN,and Caviness VS. MRI-Based Parcellation of  Human Cerebral White Matter and Nuclei. Part II: Rationale and Applications with Systematics of Cerebral Connectivity. NeuroImage, 9, 18-45, 1999.


Seidman LJ, Faraone SV, Goldstein JG, Goodman JM, Kremen WS, Toomey R., Tourville J., Kennedy DN,  

          Makris N., Caviness VS, Tsuang MT. Thalamic and amygdala-hippocampal volume reductions in first degree

          relatives of schizophrenic patients: An MRI-based morphometric analysis. Biological Psychiatry,

          46: 941-954, 1999.


Goldstein JM, Goodman JM, Seidman LJ, Kennedy DN, Makris N, Lee H, Tourville J, Caviness VS Jr, Faraone SV, Tsuang MT.  Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch Gen Psychiatry 56(6):537-47, 1999.


Caviness VS Jr, Lange NT, Makris N, Herbert MR, Kennedy DN.  MRI-based brain volumetrics: emergence of a developmental brain science. Brain Dev 21(5):289-95, 1999.


Kennedy, DN, Lange, N., Makris, N., Bates, J., Meyer, J. and Caviness, VS Jr. Gyri of the Human Neocortex: An MRI-based Analysis of Volume and Variance. Cerebral Cortex, 8:4, p. 372-384, Jun 1998.


Makris N., Worth AJ, Sorensen G., Papadimitriou GM, Wu O., Reese TG., Wedeen VJ., Davis TL., Stakes JW., Caviness VS., Kaplan E., Rosen BR., Pandya DN., Kennedy DN.  Morphometry of  in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging.  An of Neurology, 1997.


Breiter HC., Gollub RL., Weisskoff RM., Kennedy DN., Makris N., Berke JD., Goodman JM., Kantor

HL., Gastfriend DR., Riorden JP., Mathew RT., Rosen BR., Hyman SE.  Acute effects of cocaine of human brain activity and emotion.  Neuron, 1997, vol. 19, pp. 591-611


Caviness, VS Jr, Meyer, J., Makris, N., and Kennedy, DN. MRI-based topographic parcellation of human neocortex: an anatomically specified method with estimate of reliability.  Journal of Cognitive Neuroscience. 1996; 8:6 p. 566-587


Caplan, D., Hildbrandt, N., Makris, N.  Location of lesions in stroke patients with deficits in syntactic

processing in sentence comprehension.  Brain.,  (1996), 19; 933-949.


Caplan, D., Gow, D., Makris, N.  Analysis of lesions by MRI in stroke patients with acoustic-phonetic

 processing deficits.  Neurology, 1995, 45:293-298.